New vaccine is being ready to prevent Breast Cancer….

The first human trial of breast cancer vaccine started in America claims; This will prevent the most dangerous type of triple-negative breast cancer. To prevent breast cancer, the Cleveland Clinic of America has started the trial of the first phase of its vaccine. With the help of this trial, triple-negative breast cancer, the most dangerous type of cancer, can be controlled. 

The Cleveland Clinic is working closely with vaccine company Anixa Bioscience after receiving approval for a vaccine trial from the US Food and Drug Administration. Why this trial is special and what it means, let us discuss in detail- 

The new vaccine has the potential to prevent breast cancer, says Vincent Tuofi, immunologist and vaccine developer at Cleveland Clinic's Learner Research Institute. Of all the cases of breast cancer, 12 to 15 are triple-negative breast cancer patients. This is the most serious type of breast cancer. Its cases are seen more in African and American women. So it needs to be controlled. 

Before the trial, this vaccine was given to patients aged 18 to 24 years suffering from this cancer. Tumors were completely eradicated in these patients. Monitoring is being done to understand the risk of re-tumor in them. In the first phase of the trial, this vaccine will be given to the initial patients suffering from triple-negative breast cancer. To fight cancer, how much immune response is visible in their body, maybe justified with this trial. 

Patients involved in the first phase trial will be given three doses of the vaccine. The effect and side effects of the vaccine will be monitored for 2 weeks. This entire trial will be completed by September 2022. The pre-clinical trial of the vaccine was done on rats. During the trial, it was revealed that the vaccine activated the immune system and was successful in preventing breast cancer tumors. 

Research published in the journal Nature Medicines says that this vaccine is effective on other tumors. If the first human trial is successful, then this vaccine can make big changes in the medical world. 

 

Is COP 26 summit is really help for developong country......

As we know that the global economy and suddenly changing of environmental behavior is challenging to the developing countries. Conference of the Parties 26 (COP 26) means the 26th summit of Glasgow and thus, it is named COP 26. The summit is now going on with a special motto to control or minimize the carbon dioxide emission in the world. 

In ancient days, the environment supported us and we were enjoying seasonal behavior such as timely winter, summer and rainy season, etc. The main motto of this summit is zero emissions of carbon dioxide that directly affect rain that is highly essential for India because the majority of people live in villages and depend upon farming. But who is taking care?

We are all utilizing nature very cruel manner. For instance, the summit going in Glasgow faces the arrival of many jet aircraft that carry the participants from various countries and going to emit approximately 45,000 metric tons of carbon dioxide within the summit duration. 

But the question is that why we are just engaging us to make documents. Whether the discussion is being held in Glasgow is not business-oriented where many discussions may come for technology transfer etc. One way the Western countries are advising to control Carbon dioxide emission and in other hands, they want to establish many product manufacturing industries in developing countries. India is also among these countries. We are already suffering many problems regarding exceeding temperature day by day and it is being observed that gradually our environmental behavior stops supporting us. 

For instance, Kerala is known for its lush green environment and clean climate and always gets good rain that also in time but nowadays, it is seen that the climate also not supported when it is to be rain, that time drought observed. That directly affects the crop season that gives poor yielding and ultimately it affects the life of the citizens of the state. It also affects the Indian economy. 

Not only Kerala state, but also all parts of our country facing such irregular climatic variations that push our future toward the darkness. Now, whether the topic which is being discussed in Glasgow City would practically be implemented or the number of summits only increases like COP 26,27,28 and so on... 

How the heart attack happens, knowing symptoms on time can help in saving life…

Nowadays many people are losing their lives due to heart attacks even in their pre-mature life.  According to some doctors, there have also been deaths of people whose age was less than 40 or 45.   

Let us know how many types of heart attacks are there and what are their symptoms- 

1. Hypertension- Hypertension or high blood pressure is one of the most common types of heart disease. Under normal conditions, the blood exerts a specific pressure on the walls of blood vessels, which is called blood pressure. In many situations, this pressure can be so high that it starts damaging the body parts. This can be due to an increase in the amount of blood circulating in the arteries or a decrease in the diameter of the arteries. Symptoms- This condition does not cause any specific symptoms. Many people may suffer without even knowing it. However, some patients face multiple symptoms. They include headache, dizziness, shortness of breath and nose bleeds. 

2. Coronary heart disease (CHD)- Coronary heart disease is a condition that affects the arteries that supply blood to the heart. Due to many reasons, the lumen of blood vessels gets reduced, due to which the heart does not get oxygen and blood. One of the most common complications of this disease is myocardial infarction (MI), also known as a heart attack. This occurs when the artery becomes completely blocked and sufficient blood supplies the part of the heart. As a result, the cells do not have enough oxygen and they die within minutes. Symptoms- The main symptom of coronary heart disease is angina pectoris or chest pain. In most cases, it emerges after vigorous physical activity, occurs in the center of the chest, interferes with movement, and usually disappears after a few minutes of rest. Symptoms include chest pain, tiredness, difficulty in breathing, weakness all over the body, headache, dizziness.

3. Heart failure- Heart failure is one of the most serious types of heart disease. It is a diagnostic syndrome in which the heart cannot pump effectively leading to cardiac output or insufficient cardiac output. In other words, cardiac output is insufficient. Usually, when heart failure occurs, the ventricle muscles become very weak. So it doesn't shrink properly. Many changes in its structure or function can cause this. Actually, it is the last stage of some heart conditions. Symptoms include- difficulty in breathing, inability to breathe while lying down, pink sputum cough, swelling of the lower limbs, tiredness, ascites. include chest pain, tiredness, difficulty in breathing, weakness all over the body, headache, dizziness.

4. Congenital heart disease- One of the most common causes of heart problems in children is congenital heart disease. They are structural birth defects that occur early in pregnancy when the baby's heart is forming. Symptoms -  the symptoms of congenital heart disease usually appear in the early days after birth. Some of them are rapid breathing, purple lips, and difficulty in feeding, and growth problems. On the other hand, those who were born with congenital malformations and reach adulthood suffer from arrhythmia, shortness of breath, skin malaise, fatigue, and swelling in the lower limbs.  

5. Rheumatic heart disease- Various systemic diseases can affect the heart, for example, rheumatic fever.  It is a type of heart disease caused by a staphylococcus strain that attacks connective tissue, causing an autoimmune reaction. In this way it affects the muscles and valves of the heart, causing great damage in cases of rheumatic heart disease. These damages are so severe that they can cause severe heart failure and even death. The symptoms include- fever that does not exceed 101 °F, muscle and joint pain, general weakness, vomiting, gout.

6. Cardiomyopathies- Some heart diseases, such as congenital heart disease, require surgery. Cardiomyopathy is a heart disease that affects the heart muscle. They modify the size and distribution of the cells that make up it. In this way, the heart gets changed. The three most common types of cardiomyopathies are dilated, hypertrophic, and restrictive. In the first, the ventricles are enlarged. In the second the ventricular wall thickens. Finally, restrictive cardiomyopathy occurs when the walls of the heart (ventricles) harden due to infiltration of connective tissue. The Symptoms- are shortness of breath after physical activity, swelling of the lower limbs, tiredness, heart palpitation, dizziness, and fainting.

Stay healthy, stay safe...

Broken💔 Heart Syndrome is now trending disease in modern society.... be must aware of that.....

As we know that many things of life are directly correlated with our heart❤. Our heart is not only associated to pump blood to the whole body but also managing many stress, emotions, and Love❤. But do you know? Why are the people always told about the heartbroken 💔💔 story?  

Now the question is whether really heart is breaking💔💔. Many of us say, NO. Because the heart has no time even a fraction of a second to think. It keeps on continuously working and pumping blood to our whole body. If stop even a second, people hardly survive, so when is the time? 

[Broken Heart Syndrome]

Yes. Scientifically, somewhat better to argue in this but really our heart is involved in many activities that control our mood and mind😏😏. It maintains stress, provides sentiment, feels sorrow and happiness, affection, and so on..... 

Some of the people told heart is breaking💔. The heartbreaking is now common to the young generation as they are very much under stress due to study, job, life settlement, choosing their life partners, etc. Apart from that the trending lifestyle and waking late at night, sitting mental work also play a key role to give intolerable stress to heart❤and ultimately, when the stress crosses limits, it starts to give trouble to heart in many ways and inauguration of many diseases happens. 

Have you ever heard -  

" Jab Dil Hi Toot Gaya, tab Ji kar kya karein "

OR 

"Dil ka khilauna haye toot gaya" 

OR 

Dil deta hai ro ro ke duhai, kisi se koi pyaar na kare", etc. 

But it's true, the heart ❤ will not break but due to abnormalities in sleep, food, stress, lifestyle, etc., it gives more pressure on the mind, and the level of bad cholesterol increases. This cholesterol starts forming crust or plaques in important arteries of the heart, the narrowing vessels, then damage and as a result, a heart attack will come. This is called Heart is broken💔💔. 

Scientifically, Broken heart syndrome, also called stress cardiomyopathy or takotsubo cardiomyopathy, is a real condition. Although its symptoms mimic a heart attack, it's caused by sudden physical or emotional stress. Treatments include heart medications, anti-anxiety drugs, stress management, and cardiac rehabilitation. Broken heart syndrome is a temporary heart condition that's often brought on by stressful situations and extreme emotions. The condition can also be triggered by a serious physical illness or surgery. It may also be called stress cardiomyopathy, takotsubo cardiomyopathy, or apical ballooning syndrome. 

Broken heart 💔 syndrome is a condition with symptoms that may feel like a heart attack, like chest pain, and shortness of breath, but it's caused by going through an emotionally stressful event, not by clogged arteries. It's triggered by very stressful situations, like the death of someone you love. Stress may lead to high blood pressure, which can pose a risk for heart attack and stroke. Stress also may contribute to such cardiovascular disease risks as smoking, overeating, and lack of physical activity. "Chronic stress has been shown to be associated with increased cardiovascular events," Schiffrin said. 

Takotsubo cardiomyopathy 💔or "Broken Heart Syndrome" is when the heart muscle becomes suddenly stunned or weakened. It mostly occurs following severe emotional or physical stress. The condition is temporary and most people recover within two months. 

Please🙏 don't allow your mind to become a hobby upon you and rule you whatever it wants. ❤Control your emotional movement, think with mind considering that every action has a reaction either it is good or bad. 

Stay healthy, stay safe...

Custard Apple: The king fruit for winter seasons. Know the advantages and disadvantages before eating...

Custard apple (Annona squamosa) tree is a small shrub of genus Annona and the family Annonaceae. The fruit is popularly known as custard or sugar apple. In Hindi, it is called Sharifa’ or ‘Sitaphal’ in Sanskrit. Sharifa or Sitaphal is also called the king of fruits in winter.  This fruit is full of health benefits and is very sweet to eat. It is delicious in taste also. 

[Naturally ripen Custard apple]

Although it contains essential vitamins and minerals, which are necessary for our body according to the season, it is necessary to be careful before its eating. Sitaphal has started in the markets, but before eating it, definitely, we should know the advantages and disadvantages. 

Advantages of eating custard apple-

1. It is rich in vitamin C and antioxidants. 

2. Helps reduce the risk of serious diseases like cancer. 

3. Vitamin A, magnesium, fiber are present. 

4. If you are suffering from a common stomach problem, then definitely consume custard apple but in small quantities. 

5. It is good to eat custard apples during pregnancy. 

Disadvantages of eating custard apple-

1. If you have any kind of allergy or skin allergy, do not eat custard apples. This can make your face itchy more. 

2. If you are suffering from the problem of digestion, then do not consume custard apple, because it is high in fiber. Due to this, you may have problems like stomach pain, gas formation, etc. 

3. It is rich in iron. Excessive consumption can cause nausea or vomiting. 

4. If your blood pressure drops very quickly, then consume it in a limited quantity. Otherwise, eat only with the advice of the Doctor. This can have an adverse effect on health, causing dizziness or lack of water. 

5. Sitaphal is rich in calories. If you want to lose weight in the festive season, then consume it at least, because it is high in sugar. Although it is natural sugar still does harm.

6. Do not consume custard apple seed. The ingredients present in it can cause allergic reactions in your skin and eyes.

Stay healthy, stay safe...